Endocrine Abstracts

The influence of the plant lectins on binding of IGF-I, IGF-II and insulin to the cognate receptors from solubilised human placental cell membranes was examined. The lectins (wheat germ agglutinin, WGA; concanavalin A, Con A; phytohaemagglutinin, PHA and Sambucus nigra agglutinin, SNA) were chosen according to their sugar specificity and were expected to bind to the most abundant saccharides present as terminal residues on N-glycan moieties of insulin receptor (IR) and ...

Insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) have important metabolic roles in the human body. IGFBP-3 (40 and 45 kD glycoforms) is the most abundant in serum, whereas IGFBP-2 (34 kD) and IGFBP-1 (29 kD) are present at lower concentrations.Most inflammatory diseases of the gastrointestinal tract are characterised by a cytokine- mediated inflammatory reaction, malnutrition and catabolism. The aim of this work was to detect possib...

Insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) have important metabolic roles in the human body. IGFBP-3 (40 and 45 kD glycoforms) is the most abundant in serum, whereas IGFBP-2 (34 kD) and IGFBP-1 (29 kD) are present at lower concentrations.Most inflammatory diseases of the gastrointestinal tract are characterised by a cytokine- mediated inflammatory reaction, malnutrition and catabolism. The aim of this work was to detect possib...

While previous studies have shown relatively low concentrations of insulin-like growth factors (IGF)in human ejaculates, high levels of IGF binding protein-2 (IGFBP-2)have been reported. The IGF/IGFBP system was investigated in ejaculates from thirty men aged 23-46 years consulting a fertility clinic. Volume, viscosity, total and motile sperm counts were estimated by standard methods and each subject consented for the specimen to be used in this study. Local Ethical Committee ...